This domain focuses on physics-informed AI and digital twins; AI for grid optimization, resilience, and security; and trusted AI for critical infrastructure. Address quantum computing software and hybrid quantum-AI platforms; quantum sensing technologies; quantum networking and secure communications; critical infrastructure cybersecurity; and advanced energy materials and manufacturing.
AI
Physics-Informed AI and Digital Twins
Trusted AI for Critical Infrastructure, Grid Security
Hardware-software codesign for AI
Exascale and post-exascale supercomputing infrastructure (OLCF-6, ALCF-4 upgrades) to power AI training and inference at the frontier of science
Scientific foundation models and AI agents for hypothesis testing, autonomous research workflows, and experimental design
Cutting-edge AI and quantum hardware accessible to the national laboratory complex and industry partners, with new services essential to the Genesis Mission
Quantum Computing
Quantum Computing Software and Hybrid Quantum-AI Platforms
Quantum Sensing Technologies
Quantum Networking and Secure Communications
As standalone and as enabling technologies for quantum computing including interconnects
Enabling quantum computing hardware technologies:
Materials R&D for quantum materials needs
Components for various qubit platforms
“Control” electronics/processors for quantum, classical, HPC-quantum
Control for hybrid (quantum and classical processors)
Energy Security
Fusion Energy Enabling Technologies
Advanced Nuclear and Microreactor Technologies
Advanced Energy Materials and Manufacturing
Decision Support Systems (for modeling of interconnected, engineered, and natural systems for securing critical infrastructures)
Cybersecurity AI tools - adversarial ML defense, automated threat detection for critical energy infrastructure
Energy-efficient computing architectures
Los Alamos National Lab (LANL) is the domain chair for AI, Quantum Computing & Energy Security in the Cradle to Commerce program.
Los Alamos National Laboratory (LANL) is a premier national security research institution where multidisciplinary science, technology, and engineering serve the United States’ needs in nuclear deterrence, intelligence, space research, and global security. Los Alamos’ core capability areas drive specialized expertise that supports the DOE and NNSA missions, safeguards the nation, and advances fundamental discovery: through R&D on information science and technology, materials for the future, nuclear and particle futures, science of signatures, complex natural and engineered systems, and weapons systems.
Kathleen H. McDonald
Senior Commercialization Manager
Los Alamos National Lab
Domain Lead
Satya Srinivasan
Commercialization Manager
Los Alamos National Lab
Tech Transfer Expert